Rgd-targeted solid lipid nanoparticles containing asiatic acid for the treatment of cancer by tanem garanti a thesis submitted in partial fulfilment for the requirements for the. The aim of this thesis is to develop and investigate the potential application of a specific class of non-viral delivery devices, ie, solid lipid nanoparticles (slns) as a resourceful tool for delivery of therapeutics (drugs and/or nucleic acids) into cancer cells. Review article solid lipid nanoparticles- a review neha yadav, sunil khatak, udai vir singh sara raj kumar goel institute of technology, 5 km stone delhi-meerut road, ghaziabad 201003. Lipid nanoparticles in solid state: sln - solid lipid nanoparticles • produced from 1 solid lipid phd thesis, free university of berlin. Solid lipid nanoparticles (sln) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences.
Solid lipid nanoparticles (sln) are a new generation of lipid emulsions that have high drug loading capacity, controlled drug release, improved drug stability, and excellent biocompatibility that could improve the performance of a variety of pharmaceuticals [3, 4] α. Abstract solid lipid nanoparticles (slns) are a category of delivery systems applicable to various bioactive compounds in the food industry compared to conventional emulsions that have a fluidic oil phase, the mobility and release of bioactive compounds can be controlled by encapsulation in the solid lipid matrix with appropriate properties. A thesis submitted to the faculty of the graduate school of the creighton university in present research was to develop and characterize solid lipid nanoparticles.
A nanoparticle (or nanopowder or nanocluster or nanocrystal) is a microscopic particle with at least one dimension less than 100 nm nanoparticle research is currently an area of intense scientific research, due to a wide variety of potential applications in biomedical, optical, and electronic fields. Loaded lipid nanoparticles by yuechao du a thesis submitted to the graduate school-new brunswick rutgers, the state university of new jersey solid lipid. Solid lipid nanoparticles (sln) have attracted increasing attention during recent years this paper presents an overview about the selection of the ingredients, different ways of sln production and sln applications. A thesis submitted to the faculty of the university of mississippi in partial fulfillment of the derivatization and formulations such as solid lipid nanoparticles.
A novel approach to formulation of anticancer drugs in nanoparticles by xinyi gu a dissertation submitted in partial fulfillment of the requirements for the degree of. Formation of bioactive-carrier hollow solid lipid micro- and nanoparticles by junsi yang a thesis presented to the faculty of the graduate college at the university of nebraska. The author of the phd is ms ana del pozo rodríguez (vitoria, 1980), a pharmacy graduate, who defended her thesis entitled development of solid lipid nanoparticles as systems for and.
Among these, topical application of the solid lipid nanoparticles(sln) nanostructured lipid carriers (nlc) have emerged as novel systems composed of physiological lipid materials suitable for topical, dermal and transdermal administration. 1 effect of solid lipid nanoparticle-encapsulated antimicrobial peptide on keratinocyte migration and wound healing a thesis presented to the faculty of. Ostigov journal article: lamellar crystalline self-assembly behaviour and solid lipid nanoparticles of a palmityl prodrug analogue of capecitabine—a chemotherapy agent title: lamellar crystalline self-assembly behaviour and solid lipid nanoparticles of a palmityl prodrug analogue of capecitabine—a chemotherapy agent. Solid lipid nanoparticles drugdeliverytechnology september2009 vol9 no8 xx solid lipid nanoparticles for the delivery of pharmaceutical actives by:andrewloxley,phd nanoparticle.
Solid lipid nanoparticles (sln) composed of two different lipid matrices were produced to assess their in vivo toxicity in mice matrix substances were (i) compritol (glycerol behenate), a. Thus, the aim of this research work was to produce stable solid lipid nanoparticles (sln) using carnauba wax as lipidic matrix, for delivery of rosmarinic acid, to be further incorporated into food matrices. Emulsion for parenteral nutrition but the liquid lipid (oil) of the emulsion has been replaced by a solid lipid, ie, yielding solid lipid nanoparticles different production methods which are suitable for large scale. A thesis entitled formulation, characterization and evaluation of paclitaxel loaded solid lipid nanoparticles prepared by temperature modulated solidification technique.
Iii drug-polymer and drug-lipid miscibility for the development of amorphous solid dispersions and solid lipid nanoparticles a thesis submitted to the faculty of. Solid lipid nanoparticles (sln) are colloidal dispersions or particulates in the size range of 100-500 nm composed of biocompatible lipid matrix that are physiologically well tolerated when administered in-vivo [8. Abstract: nanoparticles represent a promising drug delivery system of controlled and targeted drug release they are they are specially designed to release the drug in the vicinity of target tissue.