Rose mcdermott et al, monoamine oxidase a gene (maoa) predicts behavioral aggression following provocation, proc natl acad sci, (2008) beaver et al, maoa genotype is associated with gang membership and weapon use, comprehensive psychiatry, (2009. Monoamine oxidase (mao-a) the maoa gene codes for an enzyme named monoamine oxidase monoamine oxidase breaks down neurotransmitters such as noradrenaline, adrenaline, serotonin and dopamine, and as such, plays an important role in regulating mood. The gene is called monoamine oxidase a, or maoa it produces an enzyme that breaks down neurotransmitters which activate many of the brain's circuits back in the 1990s, scientists discovered a mutation of maoa that completely switches off the activation. Monoamine oxidase a, also known as mao-a, is an enzyme that in humans is encoded by the maoa gene this gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin.
A series of hydrazine derivatives was synthesized in order to evaluate their monoamine oxidase a (mao-a) inhibitory effects mao-a inhibitory activity of 4-tosyl benzoic acid carbohydrazide was quite potent, similarly to that of the corresponding 4-benzyloxy-benzoic acid carbohydrazide and its n-cyanoethylated derivative. Monoamine oxidase a ribbon diagram of a monomer of human mao-a, with fad and clorgiline bound, oriented as if attached to the outer membrane of a mitochondrion from pdb : 2bxs. Abstract using a discovery and replication sample from a us representative data set, we show that a functional polymorphism on the maoa gene is associated with credit card borrowing behavior. Boys who carry a particular variation of the gene monoamine oxidase a (maoa), sometimes called the warrior gene, are more likely not only to join gangs but also to be among the most violent.
Monoamine oxidase a has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase a was found it has also been used in a study to investigate an association between smoking and the inhibition of maoa. Monoamine oxidase a (maoa) is an enzyme that breaks down neurotransmitters in the synapse so the job of the maoa- gene is to send signals from the cell to produce the maoa enzyme however, some humans have a low expression variant of this gene (known as maoa-l. We describe a new polymorphism upstream of the gene for monoamine oxidase a (maoa), an important enzyme in human physiology and behavior the polymorphism, which is located 12 kb upstream of the maoa coding sequences, consists of a 30-bp repeated sequence present in 3, 35, 4, or 5 copies the. Monoamine oxidase (mao) inhibition is a non-cyp mediated metabolism assay within our portfolio of in vitro adme screening services cyprotex deliver consistent, high quality data with the flexibility to adapt protocols based on specific customer requirements. Monoamine oxidase a, maoa (mim 309850), contains 15 exons and is located on chromosome xp1123 during embryonic development maoa is the main catabolic enzyme for degradation of both dopamine and norepinephrine  suggesting a possible impact on adult behavior.
Monoamine oxidase a (maoa) is a monoamine-metabolizing enzyme the gene that encodes maoa is located on the x chromosome, and a polymorphism located within the eighth exon (941tg) is associated with low (941t) or high (941g) maoa activity ( hotamisligil & breakefield, 1991 . The variant in question is an allele conveying low activity of monoamine oxidase a (maoa), an enzyme involved in regulating the metabolism of several neurotransmitters, including dopamine and serotonin, which influence brain function (shih et al,1999. Monoamine oxidase a deficiency is caused by mutations in the maoa gene this gene provides instructions for making an enzyme called monoamine oxidase a this enzyme breaks down chemicals called monoamines, including serotonin, epinephrine, and norepinephrine.
Monoamine oxidase is an intramitochondrial enzyme responsible for the breakdown of intracellular dopamine, norepinephrine, and serotonin maois inhibit monoamine oxidase , resulting in an increase in the concentration of monoamines in the synapse. Monoamine oxidase a gene (maoa) has earned the nickname warrior gene because it has been linked to aggression in observational and survey-based studies however, no controlled experimental studies have tested whether the warrior gene actually drives behavioral manifestations of these. The maoa gene provides instructions for making an enzyme called monoamine oxidase a this enzyme is part of a family of enzymes that break down molecules called monoamines through a chemical reaction known as oxidation among the monoamines broken down by monoamine oxidase a are certain chemicals. The mutated gene produced an inactive form of monoamine oxidase a that normally would help in breaking down neurotransmitters in the brain  this can explain why antisocial behaviors in males is much more prevalent than in females.
Monoamine oxidase a (maoa) gene, nicknamed the warrior gene, has been discovered to be the most compelling candidate for a gene of susceptibility for aggression. The role of the monoamine oxidase a gene in moderating the response to adversity and associated antisocial behavior: a review macià buades-rotger,1,2 david gallardo-pujol1,3 1department of personality, faculty of psychology, university of barcelona, barcelona, spain 2department of neurology, university of lübeck, lübeck, germany 3institute. Monoamine oxidase inhibitors (maois) are a class of medication used to treat depression they were introduced in the 1950s as the first drugs for depression. This essay tackled primarily on the significant link between monoamine oxidase (warrior gene) and maori behaviour specifically, this may determine the possible causes of the aggressiveness of the maori population group as observed by other researchers and scientists as explained on their arguments.
For instance, a common polymorphism in the monoamine oxidase a (maoa) gene has been associated with both antisocial behavior and also reductions in the volume of the amygdala and orbitofrontal (ventral prefrontal) cortex—brain structures that are found to be compromised in antisocial individuals. The maoa gene, located on the x chromosome, encodes for monoamine oxidase a (maoa), an enzyme that breaks down amine neurotransmitters, such as norepinephrine, serotonin, and dopamine (raine, 2008. Monoamine oxidase a gene (maoa) has earned the nickname warrior gene because it has been linked to aggression in observational and survey-based studies however, no controlled experimental studies have tested whether the warrior gene actually drives behavioral manifestations of these tendencies. 10 masato nakatome, zaw tun, shigeko shimada, katsuya honda, detection and analysis of four polymorphic markers at the human monoamine oxidase (mao) gene in japanese controls and patients with parkinson's disease, biochemical and biophysical research communications, 1998, 247, 2, 452crossref.